Syntaxin 13 is an integral membrane protein
that belongs to the t- SNARE family, a group of proteins involved
in protein transport. Confocal immunofluoresence and electron microscopy
studies have shown that syntaxin 13 is primarily localized to tubular
early and recycling endosomes, where it colocalizes with transferrin
receptor, and it is also localized in endosomal vacuoles. Syntaxin
13 has been found to be expressed in all tissues, with higher levels
of the protein found in brain, lung, spleen, thymus and testes.
Immunoprecipitation studies show that syntaxin 13 complexes with
SNAP, VAMP2/3, and SNAP25. The binding of this complex to SNAP
and NSF is terminated in the presence of ATP . These results suggest
that syntaxin 13 is a SNARE protein which mediates the recycling
protein flow through tubulo-vesicular recycling endosomes.
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