a-glucosidase II is a 110 kDa glycosylated
endoplasmic reticulum resident protein that is involved in trimming
of glucose from newly synthesized glycosylated proteins in the
endoplasmic reticulum (ER). Together with an 80 kDa ß subunit,
these polypeptides remove two a-1,3-linked glucose from high mannose
oligosaccharides linked to asparagine residue on glycoprotein .
a-glucosidase II mediated glucose trimming is necessary for the
interaction of substrates such as influenza virus hemagglutinin
(HA) , MHC Class I , and T-cell antigen receptor (TCR) with calnexin,
an ER resident chaperon that is specific for monoglucosylated glycoproteins.
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