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ORGANELLE MARKERS - Endoplasmic Reticulum - Membrane




rBet1 is a 17 kDa transmembrane protein that mediates protein transport between endoplasmic reticulum (ER) and the Golgi apparatus. rBet1 serves as the vesicle SNAP receptor (v-SNARE) on ER-derived vesicles, which interacts with its partner t-SNARE on the Golgi apparatus during vesicle docking and fusion. rBet1 is found in a complex with syntaxin 5, GS27/membrin, GOS28, rsec22 and rsly1. Antibodies to rBet1 have been shown to inhibit the transfer of vesicular stomatitis virus G-protein from the ER to the Golgi apparatus in a cell free assay, providing evidence for the involvement of rBet1 in ER to Golgi transport.


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