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ORGANELLE MARKERS - Endoplasmic Reticulum - Membrane


Ethanol-inducible cytochrome P450 IIE1 (CYP2E1)


Ethanol-inducible cytochrome P450 IIE1 (CYP2E1) is considered one of the major causes of oxidative stress in the liver following ethanol treatment. Radicals produced by this enzyme are thought to induce lipid peroxidation reactions and other damage to the cells and to be a major cause for ethanol-dependent liver toxicity. The importance of CYP2E1 lies in its ability to metabolize a wide range compounds such as organic solvents, acetaminophen, dimethylnitrosaoamine and aliphatic alcohols, which have relevant toxicological effects in humans. To date, over 75 substrates of CYP2E1 have been identified. CYP2E1 is mainly found in the liver although it has also been detected in a variety of other organs, including the brain, colon and lungs. In the liver it is localized to the centrilobular region, specifically the hepatocyte layers most proximal to the central vein . Cytochrome P450 is considered to be part of the mixed function oxidase (MFO) sytem along with NADPHcytochrome P450 reductase.


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