GS28, also known as p28 or GOS28, is a 28 kDa
integral membrane protein on the surface of the Golgi apparatus
that serves as a t- SNARE in ER to Golgi transport. The amino-terminal
of GS28/GOS28 is exposed to the cytosol and is anchored to ths
cis Golgi via a 20 amino acid carboxyl-terminal hydrophobic tail.
GS28 co-immunoprecipitates complexes consisting of syntaxin 5,
rbet1, membrin, rsec22, and rsly1, and is therefore implicated
in ERto- Golgi or intra-Golgi vesicle transport. ATP hydrolysis
by NSF in the presence of SNAP causes the dissociation of GOS28
and syntaxin 5 complex.
- back - complete