Syntaxin 6 is a 35
kDa type II integral membrane protein with two coiled-coil domains
and a carboxyl-terminal membrane anchor (2). Immunoelectron microscopy
studies show that syntaxin 6 is primarily localized to the trans-Golgi
network (TGN), and is partially co-localized with AP-1 on clathrincoated
membranes. During secretory granule maturation, syntaxin 6 and
MPR-ligand complexes are postulated to be transferred from immature
granules to endosomes by clathrincoated vesicles, as evidenced
by immunoelectron microscopy . These results suggest that syntaxin
6 mediates a TGN trafficking targeting endosome.
- back - complete
text - |
