Lysosome-associated membrane proteins (LAMP1),
also known as lgp120 or lgpA, is a type 1 integral membrane protein
that is transported from trans-Golgi network to endosomes and then
lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane
is dependent on a carboxyl-terminal tyrosine based motif (YXXI).
Perturbation in the spacing between the tyrosine based motif relative
to the membrane abolishes lysosome localization of LAMP1. This
mutant protein then cycles between the plasma membrane and the
endosome . Cell surface LAMP1 and LAMP2 have been shown to promote
adhesion of human peripheral blood mononuclear cells (PBMC) to
vascular endothelium, therefore they are possibly involved in the
adhesion of PBMC to the site of inflammation.
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