The Voltage-Dependent Anion Channel (VDAC or
mitochondrial Porin) is an outer membrane mitochondrial protein.
The VDAC protein is thought to form the major pores through which
adenine nucleotides are transferred through the outer mitochondrial
membrane.
VDAC has also been implicated in the formation of the mitochondrial
permeability transition pore complex in apoptotic cells. This complex,
formed by VDAC, adenine nucleotide translocator (ANT), and cyclophilin
D (CypD), is thought to allow the mitochondria to undergo metabolic
uncoupling and irreversible morphologic changes that ultimately
destroy the mitochondria during apoptosis.
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