c-jun is the cellular homolog of the avian
sarcoma virus 17 transforming protein, v-jun. It is a 39 kDa (predicted
molecular mass) transcriptional activator that is part of the transcriptional
complex called AP1 and is a member of the b-ZIP family of proteins.
c-jun forms homo/heterodimers with Jun, Fos, ATF, or other trancriptional
factors through its leucine zipper domain. Transcription by c-jun
is induced by cellular exposure to growth factors, cytokines, UV
light and other DNA damaging agents. Activity of c-jun is activated
by phosphorylation of serine 63 and serine 73 residues by JNK (c-jun
N-terminal kinase). Recent studies have shown that c-jun plays
an important role in neuronal apoptosis, regeneration and protection.
- back - complete
text - |
