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Estrogen Receptors


The Estrogen Receptors (ER), are members of the nuclear steroid hormone receptor family and are also found in the plasma membrane. Steroid hormone receptors are composed of three domains, an N-terminal domain required for maximal transactivation function (TAF), a DNA binding domain and a steroid binding domain. The DNA binding domain is separated from the steroid binding domain by a hinge region. The DNA binding domain has a high degree of homology amongst the various steroid hormone receptors, followed by the steroid binding domain. The N-terminus is the most divergent region among members of the steroid receptor family.


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