The Estrogen Receptors (ER), are members of
the nuclear steroid hormone receptor family and are also found
in the plasma membrane. Steroid hormone receptors are composed
of three domains, an N-terminal domain required for maximal transactivation
function (TAF), a DNA binding domain and a steroid binding domain.
The DNA binding domain is separated from the steroid binding domain
by a hinge region. The DNA binding domain has a high degree of
homology amongst the various steroid hormone receptors, followed
by the steroid binding domain. The N-terminus is the most divergent
region among members of the steroid receptor family.
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