Peroxisomes are single membrane organelles
which are involved with many important biochemical pathways and
are found in almost all eukaryotic cells. Various toxins including,
phenols, alcohols, and aldehydes are targeted for modification
by peroxisomes. Long chain fatty acid metabolism via beta-oxidation
is also mediated by this organelle. Loss of peroxisomal functions
may result in diseases such as Zellweger syndrome, hyperpipecolic
acidemia, neonatal adrenoleukodystrophy, and infantile Refsum’s
disease. Peroxisomal Membrane Protein 70 (PMP 70) is an abundant,
integral membrane protein of the peroxisome. This protein is induced
by treatment with hypolipidemic agents in parallel with peroxisome
proliferation and stimulation of the peroxisomal beta-oxidation
enzymes.
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