Catalase is a homotetrameric heme-containing enzyme present within the matrix
of allperoxisomes. It carries out adismutationreaction in which hydrogen peroxide
is converted to water and oxygen. Human catalasehas the last four amino acids
(-KANL) at the extreme C-terminus for peroxisome targeting. The monomer of
humancatalaseis 61.3kDa in molecular size. Catalasehas been implicated as an
important factor in inflammation, mutagenesis, preven-tionof apoptosis, and
stimulation of a wide spectrum of tumors. Loss of catalase leads to the human
genetic disease, acatalasemia, or Takahara’s disease .
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