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ORGANELLE MARKERS - Peroxisome

 

Catalase

 


Catalase is a homotetrameric heme-containing enzyme present within the matrix of allperoxisomes. It carries out adismutationreaction in which hydrogen peroxide is converted to water and oxygen. Human catalasehas the last four amino acids (-KANL) at the extreme C-terminus for peroxisome targeting. The monomer of humancatalaseis 61.3kDa in molecular size. Catalasehas been implicated as an important factor in inflammation, mutagenesis, preven-tionof apoptosis, and stimulation of a wide spectrum of tumors. Loss of catalase leads to the human genetic disease, acatalasemia, or Takahara’s disease .

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