++++ Organelle Markers - powered by Acris Antibodies ++++ Here are the antibodies you are looking for ++++

     Organelle Markers
  powered by   Acris Antibodies    

HomeAcris AntibodiesAntibody Location ServiceContact usImprint


Acris Antibodies


Neuromics Antibodies


US Biologicals


Novus Biologiacals






ORGANELLE MARKERS - Plasma membrane




Fas/APO-1/CD95 is a 36 kDa cell surface type I-membrane glycoprotein with an apparent molecular weight of 44 kDa on SDSPAGE. Fas is a member of the tumor necrosis factor receptor (TNFR) family, which includes TNFR1, TNFR2, CD27, CD30 and CD40. Binding of Fas-ligand (FasL) to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies leads to apoptosis of Fas expressing cells. Both Fas and TNFR contain a 70 amino acids cytoplasmic .death domain. that is responsible for transmitting signal for apoptosis. Apoptosis induced by Fas-Fas ligand interaction is inhibited by a number of cytosolic factors such as the ICE/CED3 family inhibitor CrmA, and the short and long form of FLIP. Insertion of an early transposable element in intron 2 of Fas structural gene, as in the mouse lpr mutations, causes lymphoproliferation and autoimmunity in mutant mice, suggesting that Fas is involved in clonal deletion of autoreactive T cells.


  -  back  -  complete text  -  




© 2004-2010 Acris Antibodies   -   All rights reserved   -   Imprint