Fas-associating death domain containing protein
(FADD)/MORT1 is a 23 kDa cytosolic protein, with an apparent molecular
mass of 28 kDa on SDS PAGE, that serves as a signal transducer
of Fasinduced ap. FADD contains a death domain homologous to that
of Fas and interacts with the cytoplasmic death domain of Fas in
order to initiate the apoptotic signalling cascade. Through its
amino-terminal death effector domain (DED), FADD binds to cytosolic
proteins such as TRADD, a cytosolic death domaincontaining protein
that asssociates with the cytosolic portion of TNF receptor, or
MACH/FLICE/caspase-8, a protease with sequence homology to ICE-CED-3
protease family, in order to transduce the death signal. The FADD-FLICE
containing signalling complex is inhibited by a number of cytosolic
factors such as the ICE/CED3 family inhibitor CrmA, which inhibits
the protease activity of FLICE, and the short and long form of
FLIP, which bind to FADD-FLICE complex.
- back - complete
text -
|
