RIP-associated ICH-1/CED-3-homologous protein
with a death domain (RAIDD) is a 23 kDa cytosolic protein that
serves as the adaptor molecule that couples receptor signalling
complex and ICElike cysteine proteases that cleave cellular enzymes
critical to cell survival. RAIDD contains an amino-terminal domain
that is homologous to the prodomain of two caspases: human ICH-1
and C. elegans CED-3. Its carboxyl-terminus contains a death domain
that interacts with the homologous domain on a serine-threonine
kinase component of the signalling pathway, RIP. Mutations within
the amino-terminal domain of RAIDD similar to those that inactivate
CED-3, prevents homophilic binding of RAIDD.
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