++++ Organelle Markers - powered by Acris Antibodies ++++ Here are the antibodies you are looking for ++++

     Organelle Markers
  powered by   Acris Antibodies    

HomeAcris AntibodiesAntibody Location ServiceContact usImprint


Acris Antibodies


Neuromics Antibodies


US Biologicals


Novus Biologiacals






ORGANELLE MARKERS - Plasma membrane - peripherial




Growth factor receptor-bound protein 2 (Grb2), also known as Ash protein, is a 24 kDa protein that contains a central Src homology (SH2) domain flanked by two SH3 domains. Grb2 is believed to be a regulatory subunit of signaling molecules whose activity is modulated by receptor binding. Grb2 associates with activated (tyrosine phosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNK through SH2 and SH3 domains. The SH3 domain binds to SOS, a guanine nucleotide exchange factor for Ras proteins. Endocytosis of activated EGFR requires the interaction of Grb2 with the GTP binding protein dynamin, a factor essential to the formation of endocytotic vesicle. It is ubiquitously expressed and several isoforms are produced by alternative splicing. On SDS-PAGE, Grb2 has an apparent molecular weight of 28 kDa.


  -  back  -  complete text  -  




© 2004-2010 Acris Antibodies   -   All rights reserved   -   Imprint