Cadherins are calcium dependent cell adhesion
molecules, which play important role in the growth and development
of cells via the mechanisms of control of tissue architecture and
the maintenance of tissue integrity. They are expressed in tissue
specific manner and and are required for assembly of cells into
solid tissue. Individual cadherin molecules are known to co-operate
with each other to form a linear cell adhesion zipper. In adhesion
junctions cadherins are bound to beta and gamma catenins which
in turnbind to alpha catenin, an actin binding protein. Cadherins
play important part in tumor invasion and metastasis.
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