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ORGANELLE MARKERS - Plasma membrane - peripherial

 

Cadherin (pan)

 

Cadherins are calcium dependent cell adhesion molecules, which play important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. They are expressed in tissue specific manner and and are required for assembly of cells into solid tissue. Individual cadherin molecules are known to co-operate with each other to form a linear cell adhesion zipper. In adhesion junctions cadherins are bound to beta and gamma catenins which in turnbind to alpha catenin, an actin binding protein. Cadherins play important part in tumor invasion and metastasis.

 

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