CD27 (50 kDa) is a member of the tumor necrosis
factor (TNF) receptor superfamily. CD40 and CD30 are also members
of the TNF receptor superfamily. The TNF superfamily members are
known for the regulation of cell proliferation and death. In contrast
to the expression of other TNFR/TNF family members, expression
of CD27 and its ligand CD70 is predominantly confined to lymphocytes.
High expression levels of CD27 appear to be dependent on proper
ligation of antigen receptors. CD70 expression requires additional
co-stimulatory and/or pro-inflammatory signals. CD27 is a membranebound
receptor, but a soluble form of CD27 is also produced. Soluble
CD27 is found in body fluids and can be used to monitor local and
systemic immune activation. In addition, elevated serum concentrations
of soluble CD27 are found in patients with B cell malignancies
and soluble CD27 levels strongly correlate with tumor load.
- back - complete