Grp78, a 78 kDa glucose-regulated protein, also
known as BiP or immunoglobulin heavy chain binding protein, is a stress-response
protein which is induced by agents or conditions that adversely affect
endoplasmic reticulum (ER) function . This protein is essential for
the proper glycosylation, folding and assembly of many membrane bound
and secreted proteins . Grp78 is critical for maintenance of cell homeostasis
and the prevention of apoptosis . Grp78 protein levels have been shown
to be a reliable biomarker of hypoglycermia as well as serving a neuroprotective
function in neurons exposed to glutamate and oxidative stress .Grp78
levels are reduced in the brains of Alzheimer.s Disease patients and
decreased expression of Grp78 is found associated with missense mutations
in the human presenilin-1 (PS1) gene . The induction of the Grp78 protein
has been associated with the development of drug-resistance to antitumor
drugs.
- back - complete
text -
|
