ORGANELLE MARKERS - Endoplasmic Reticulum

Glucosidase II

a-glucosidase II is a 110 kDa glycosylated endoplasmic reticulum resident protein that is involved in trimming of glucose from newly synthesized glycosylated proteins in the endoplasmic reticulum (ER). Together with an 80 kDa ß subunit, these polypeptides remove two a-1,3-linked glucose from high mannose oligosaccharides linked to asparagine residue on glycoprotein . a-glucosidase II mediated glucose trimming is necessary for the interaction of substrates such as influenza virus hemagglutinin (HA) , MHC Class I , and T-cell antigen receptor (TCR) with calnexin, an ER resident chaperon that is specific for monoglucosylated glycoproteins.

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