ORGANELLE MARKERS - Golgi

GS28

GS28, also known as p28 or GOS28, is a 28 kDa integral membrane protein on the surface of the Golgi apparatus that serves as a t- SNARE in ER to Golgi transport. The amino-terminal of GS28/GOS28 is exposed to the cytosol and is anchored to ths cis Golgi via a 20 amino acid carboxyl-terminal hydrophobic tail. GS28 co-immunoprecipitates complexes consisting of syntaxin 5, rbet1, membrin, rsec22, and rsly1, and is therefore implicated in ERto- Golgi or intra-Golgi vesicle transport. ATP hydrolysis by NSF in the presence of SNAP causes the dissociation of GOS28 and syntaxin 5 complex.

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