ORGANELLE MARKERS - Golgi

Syntaxin 6

Syntaxin 6 is a 35 kDa type II integral membrane protein with two coiled-coil domains and a carboxyl-terminal membrane anchor (2). Immunoelectron microscopy studies show that syntaxin 6 is primarily localized to the trans-Golgi network (TGN), and is partially co-localized with AP-1 on clathrincoated membranes. During secretory granule maturation, syntaxin 6 and MPR-ligand complexes are postulated to be transferred from immature granules to endosomes by clathrincoated vesicles, as evidenced by immunoelectron microscopy . These results suggest that syntaxin 6 mediates a TGN trafficking targeting endosome.

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