ORGANELLE MARKERS - Nucleus

c-jun

c-jun is the cellular homolog of the avian sarcoma virus 17 transforming protein, v-jun. It is a 39 kDa (predicted molecular mass) transcriptional activator that is part of the transcriptional complex called AP1 and is a member of the b-ZIP family of proteins. c-jun forms homo/heterodimers with Jun, Fos, ATF, or other trancriptional factors through its leucine zipper domain. Transcription by c-jun is induced by cellular exposure to growth factors, cytokines, UV light and other DNA damaging agents. Activity of c-jun is activated by phosphorylation of serine 63 and serine 73 residues by JNK (c-jun N-terminal kinase). Recent studies have shown that c-jun plays an important role in neuronal apoptosis, regeneration and protection.

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