Organelle Markers
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Poly (ADP-ribose) polymerase (PARP)


Poly (ADP-ribose) polymerase (PARP) is a 113kDa nuclear protein that is involved in DNA repair and is an early marker of apoptosis. PARP is activated by DNA strand breaks to produce poly (ADPribose) polymers and attach them to nuclear proteins such as histone, topoisomerase, DNA-dependent Protein kinase,and itself. PARP contains an amino terminal zinc-finger containing-DNA binding domain, an automodification domain and a carboxyl-terminal catalytic domain. Upon induction of apoptosis in HL-60 cells treated with etoposide, PARP is cleaved by caspase between Asp 214 and Gly-215 into an 85kDa and a 29kDa fragment. PARP-knock out mice display no phenotypic abnormalities, and apoptosed normally in response to TNF, ?-radiation, dexamethasone, suggesting PARP is dispensable for apoptosis.


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