Catalase is a homotetrameric heme-containing enzyme present within the
matrix of allperoxisomes. It carries out adismutationreaction in which
hydrogen peroxide is converted to water and oxygen. Human catalasehas
the last four amino acids (-KANL) at the extreme C-terminus for peroxisome
targeting. The monomer of humancatalaseis 61.3kDa in molecular size.
Catalasehas been implicated as an important factor in inflammation,
mutagenesis, preven-tionof apoptosis, and stimulation of a wide spectrum
of tumors. Loss of catalase leads to the human genetic disease, acatalasemia,
or Takahara’s disease .
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